Chick "Thunder" Hicks is a recurring antagonist in the Disney/Pixar Cars franchise He serves as the main antagonist of Pixar's 7th full-length animated feature film, Cars, a minor character in its 2017 threequel Cars 3

Randall "Randy" Boggs is the central antagonist of Pixar's fourth full-length animated feature film Monsters Inc. and a major antagonist in its prequel film Monsters University.

Sir Miles Axlerod, also simply known as Sir Axlerod, is the main antagonist of Pixar's 12th full-length animated feature film Cars 2, the second installment of the Cars film series.

Nana is a minor antagonist in DreamWorks' 10th full-length animated feature film Madagascar, the central antagonist of The Madagascar Penguins in a Christmas Caper the secondary antagonist of Madagascar: Escape 2 Africa, and the main antagonist of its eponymous video game tie-in.

Zurg is the main antagonist of Pixar's 26th full-length animated feature film Lightyear, a Toy Story spin-off prequel film centered on Buzz Lightyear

Buddy Pine, formerly known as IncrediBoy and better known as Syndrome is the main antagonist of Pixar's 6th full-length animated feature film The Incredibles and a cameo antagonist in the short film Jack-Jack Attack.

Lots-o'-Huggin' Bear, more commonly known as Lotso for short, is the main antagonist of Pixar's 11th full-length animated feature film Toy Story 3.

Evelyn Deavor, also better known by her supervillain name the Screenslaver, is the main antagonist of Pixar's 20th full-length animated feature film Incredibles 2.

Tai Lung is a major antagonist in the Kung Fu Panda franchise He is the main antagonist of DreamWorks' sixteenth full-length animated feature film Kung Fu Panda, the posthumous overarching antagonist of its 2010 TV short Kung Fu Panda Holiday

In The Adventures of IronTony, he is a minor antagonist of season 2, The main antagonist of seasons 3-4, the secondary antagonist of seasons 5-6, and the final antagonist of season 7.

Dwayne LaFontant, also known as the Verminator, is one of the two secondary antagonists (alongside Gladys Sharp) of DreamWorks' 12th full-length animated feature film Over the Hedge (which is based on the 1995 syndicated comic strip of the same name by Michael Fry and T. Lewis),

Makunga is the main antagonist of DreamWorks' seventeenth full-length animated feature film Madagascar: Escape 2 Africa. He is Zuba's arch-nemesis and Teetsi's boss.

Captain Gutt is the main antagonist of Blue Sky's 7th animated feature film Ice Age: Continental Drift and a posthumous antagonist in the 2016 TV special, Ice Age: The Great Egg-Scapade

Charles F. Muntz, also simply known as Charles Muntz or sometimes known by his surname Muntz, is the main antagonist of Pixar's tenth full-length animated feature film Up,

Shaw is the main antagonist of the Open Season franchise. He is the main antagonist of Sony Pictures Animation's first feature film Open Season and Open Season: Scared Silly and the unseen overarching antagonist of Open Season 2 and Open Season 3.

Alameda Slim is the main antagonist of Disney's fourty-fifth full-length animated feature film Home on the Range He is Maggie, Grace and Mrs. Calloway's archenemy.